The Collegio di Spagna (Royal Spanish College or Royal College of Spain in Bologna) (officially Real Colegio Mayor de San Clemente de los Españoles) is a college for Spanish students at the University of Bologna, Italy, which has been functioning since the 14th century. Its full original name in English translation was the Royal College of Saint Clement of the Spaniards. It has been under the Royal patronage of the Spanish Crown since 1488, as authorized by Pope Innocent VIII.

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