Sant'Ambrogio e Carlo al Corso (usually known simply as San Carlo al Corso) is a basilica church in Rome, Italy, facing onto the central part of the Via del Corso. The apse of the church faces across the street, the Mausoleum of Augustus on Via di Ripetta.

This church is dedicated to Saint Ambrose and Saint Charles Borromeo, the patron saints of Milan. It is one of at least three churches in Rome dedicated to Borromeo, others including San Carlo ai Catinari and San Carlo alle Quattro Fontane.

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